The term “pharmacology” is derived from two Greek words: pharmakon, the Greek word for drugs, and logos, the Greek word for science. It is a branch of science that deals with the study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting normal body processes. These substances may be chemicals administered to achieve a beneficial therapeutic effect on some process within the patient or for their toxic effects on regulatory processes in parasites infecting the patient.
The history of pharmacology is as old as man himself. Early man undoubtedly recognized the medicinal or toxic effects of many plant and animal materials. Belief in the curative powers of these materials rested exclusively upon traditional knowledge, that is, empirical information not subjected to critical examination. These knowledge were passed down through generations. Whatever has been used from the earliest times in the form of superstition, primitive material medica, herbal, traditional, magic and witchcraft metamorphosed now into a highly organized science in its own right called pharmacology.
Pharmacology has two major branches:
Others branches of pharmacology include clinical pharmacology, neuropharmacology, psychopharmacology, pharmacotherapeutics, pharmacogenetics, pharmacogenomics, toxicology, chemotherapy, posology, pharmacoeconomics, pharmacoepidemiology, molecular pharmacology, immunopharmacology, pharmacometrics etc.
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The word “drug” is derived from the old French word “drogue” which means a “dry herb”. It is defined as any substance or product which when administered to a living organism, influences biological functions. Drugs can also be defined as any substance that is used or intended to be used to modify or explore physiological systems or pathological states for the benefit of the recipient.
The terms “drug” and “medicine” are often mistakenly used by most people (practitioners and laymen alike) without any marked distinction. However, in the strictest sense, the two have different meanings, and they can serve different purposes.
The major sources of drugs can be grouped into the following
Many plants have been used for centuries as drugs or drug sources. These include leaves, barks, fruits, roots, stem, wood, seeds, blossoms, bulb etc. Drugs from plants may either be used without further processing (crude drugs) or with technical processing (prepared drugs).
Some pharmacologically active principles or drugs derived from plant sources include digoxin and digitoxin (from Digitalis purpurea/foxglove plant), atropine (from Atropa belladonna), quinine (from Cinchona), tubocurarine (from Chondrodendron tomentosum) etc.
Several life-saving drugs have been derived from microorganisms. Examples include penicillin produced by Penicillium chrysogenum, streptomycin from Streptomyces griseus, chloramphenicol from Streptomyces venezuelae, neomycin from Streptomyces fradiae, bacitracin from Bacillus subtilis etc.
Many important drugs are derived from animal source. In most instances, these medicinal substances are derived from the animal’s body secretions, fluid or glands. Animal sources include cod liver oil from Gadus spp., insulin from bovine or porcine pancreas, hirudin obtained from the European medical leech (Hirudo medicinalis), heparin from Mexican medical leech (Hirudo manillensis) etc. Like plant products, drugs from animal sources may be crude (unrefined) or refined material.
Coral, sponges, fish, and marine microorganisms produce biologically potent chemicals used in the prevention, treatment or cure of many diseases. A good example of such chemicals is Curacin A, a potent cytotoxic agent from marine cyanobacterium Lyngbya majuscule. Other examples include eleutherobin from coral Eleutherobia sp., discodermolide from marine sponge Discodermia dissoluta, etc.
Chemically pure forms of both metallic and non-metallic minerals are useful pharmacotherapeutic agents. For examples, ferrous sulfate used in iron deficiency anaemia, magnesium sulphate used as purgative; magnesium trisilicate, aluminium hydroxide and sodium bicarbonate used as antacids for hyperacidity and peptic ulcer etc.
Radioactive isotopes of iodine, phosphorus, gold are increasingly becoming important in medicine both for diagnosis and treatment of diseases particularly malignant conditions.
Semi-synthetic drugs are generally made by chemically modifying substances that are available from natural source to improve its potency, efficacy and/or reduce side effects. In semi-synthetic drugs, the nucleus of drug obtained from natural source is kept intact but the chemical structure is altered.
Examples of semi-synthetic medicine include heroin from morphine, bromoscopolamine from scopolamine, ampicillin from penicillin etc.
Synthetic drugs are manufactured in pharmaceutical or chemical laboratories using chemical synthesis, which rearranges chemical derivatives to form a new compound. They may be either organic or inorganic or a combination of both.
At present, majority of drugs used in clinical practice are prepared synthetically. One of the earliest synthetic drugs was sulphonamide, which began with the synthesis of prontosil dye. Other examples include aspirin, acetaminophen, chloroquine etc.
This is relatively a new field which is being developed by mixing discoveries from molecular biology, recombinant DNA technology, DNA alteration, gene splicing, immunology, and immune pharmacology. Examples include recombinant Hepatitis B vaccine, recombinant insulin and others.
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Throughout the process of development, drugs may have several names assigned to them. These names are the drug’s chemical name, generic name, and brand name.
This gives the exact chemical makeup of the drug and indicates the arrangement and position of atoms or atomic groups. A chemical name looks strange to anyone who is not a chemist and is difficult for most people to pronounce e.g., 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid Hydrochloride.
This is the name with which the drug is described in official books of reference like pharmacopoeias e.g., ciprofloxacin.
This is the name given to a drug by its manufacturer. This name is often followed by the symbol ® which indicates that the name is registered to a specific manufacturer and no one else can use that name. Examples include Ciloxan®, Cipro®, Neofloxin® etc.
Drugs can be administered through several routes, which are sometimes referred to as transitory passages. The major routes of administration include:
Read More on Routes of Drug Administration
Drugs have multiple effects on the body. The effect produced by drugs can be recognised only as a change in a function or process that maintain the existence of the living organism since all drugs act by causing changes in some known physiological functions and processes.
Some of these effects are desirable and some are not. The therapeutic effect is the intended physiological effect or the reason the drug is being given. This can be the drug’s action against a disease such as an antibiotic destroying or slowing down the growth of bacteria. Another physiological effect can be the side effects that occur in the body such as nausea and vomiting or a skin rash.
A side effect is a physiologic effect that is not the intended action such as the drowsiness that occurs when a patient takes first-generation antihistamine. Some side effects are beneficial while others are adverse effects that can be harmful to a patient.
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